Equivocal evidence this substance is a weak skin sensitizer based on limited animal testing.
|
some
|
M. Lavelle, Y. Tokura, Y. Thakkar, G. Sullivan, I. G. Sipes, F. Siddiqi, D. Selechnik, T. W. Schultz, N. Sadekar, J. Romine, G. Ritacco, T. M. Penning, M. Na, H. Moustakas, D. C. Liebler, I. Lee, A. M. Api, A. Lapczynski, M. Kumar, K. Joshi, L. Jones, A. D. Fryer, C. Deodhar, W. Dekant, M. Date, M. L. Dagli, M. A. Cancellieri, J. Buschmann, G. A. Burton, M. Bruze, D. Botelho & D. Belsito. 2021. RIFM fragrance ingredient safety assessment, naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, CAS Registry Number 6790-58-5. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 112454.
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ToxCast Model predicts andorgen receptor agonist activity.
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
No evidence of reproductive toxicity in animal testing.
|
low
|
M. Lavelle, Y. Tokura, Y. Thakkar, G. Sullivan, I. G. Sipes, F. Siddiqi, D. Selechnik, T. W. Schultz, N. Sadekar, J. Romine, G. Ritacco, T. M. Penning, M. Na, H. Moustakas, D. C. Liebler, I. Lee, A. M. Api, A. Lapczynski, M. Kumar, K. Joshi, L. Jones, A. D. Fryer, C. Deodhar, W. Dekant, M. Date, M. L. Dagli, M. A. Cancellieri, J. Buschmann, G. A. Burton, M. Bruze, D. Botelho & D. Belsito. 2021. RIFM fragrance ingredient safety assessment, naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, CAS Registry Number 6790-58-5. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 112454.
|
No evidence of genotoxicity in in vitro testing.
|
low
|
M. Lavelle, Y. Tokura, Y. Thakkar, G. Sullivan, I. G. Sipes, F. Siddiqi, D. Selechnik, T. W. Schultz, N. Sadekar, J. Romine, G. Ritacco, T. M. Penning, M. Na, H. Moustakas, D. C. Liebler, I. Lee, A. M. Api, A. Lapczynski, M. Kumar, K. Joshi, L. Jones, A. D. Fryer, C. Deodhar, W. Dekant, M. Date, M. L. Dagli, M. A. Cancellieri, J. Buschmann, G. A. Burton, M. Bruze, D. Botelho & D. Belsito. 2021. RIFM fragrance ingredient safety assessment, naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, CAS Registry Number 6790-58-5. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 112454.
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