nhalation of A. nobilis oil or one of its components elicited behavioral changes in rats.
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some
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Yingying Kong, Ting Wang, Rong Wang, Yichuan Ma, Shanshan Song, Juan Liu, Weiwei Hu & Shengtian Li. 2017. Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats. Science China. Life sciences 60(6), 647-655.
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Weak evidence of possible pregnancy/birth effects associated with chamomile consumption.
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some
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Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni. 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
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May cause an allergic skin reaction
Only in: Household Cleaners
|
some
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European Chemicals Agency (ECHA): GHS Data from ECHA Website
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Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
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Derivatives of this species demonstrate neuromuscular effects in animals.
|
some
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Zsolt Sándor, Loránd Barthó, Róbert Papp, Dezső Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & Dezső Csupor. 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323.
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The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
|
some
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Cosmetic Ingredient Review (CIR): CIR Assessments
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Allergic skin reaction observed in human case study.
|
some
|
B. C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
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Animal testing shows evidence of antiinflammatory effects.
|
low
|
T. Rossi, M. Melegari, A. Bianchi, A. Albasini & G. Vampa. 1988. Sedative, anti-inflammatory and anti-diuretic effects induced in rats by essential oils of varieties of Anthemis nobilis: a comparative study. Pharmacological research communications 20 Suppl 5, 71-4.
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A review article reports this substance may have anticarcinogenic activity
|
low
|
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
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A peer-reviewed study reports that botanical oils prevent oxidative damage.
|
low
|
Kevin P. Anthony, Suziat A. Deolu-Sobogun & Mahmoud A. Saleh. 2012. Comprehensive assessment of antioxidant activity of essential oils. Journal of food science 77(8), C839-43.
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This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
|
low
|
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
|
A review article reports this substance is not mutagenic
|
low
|
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
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