|
Clear evidence of endocrine disruption in at least one animal study
|
some
|
EU Endocrine: EU Endocrine Disrupters
|
|
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
|
some
|
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
|
|
Asthmagen (sensitizing)
|
some
|
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Asthmagen (sensitizing)
|
some
|
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
|
some
|
EU Ecolabel: Detergents Ingredients Database
|
|
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
|
some
|
EU Ecolabel: Detergents Ingredients Database
|
|
This review article reports triclosan can act as an endocrine disruptor
|
some
|
Andrea B. Dann & Alice Hontela. 2011. Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of applied toxicology : JAT 31(4), 285-311.
|
|
risk of promoting bacterial resistance
|
some
|
Gilles Bedoux, Benoit Roig, Olivier Thomas, Virginie Dupont & Barbara Le Bot. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environmental science and pollution research international 19(4), 1044-65.
|
|
risk of developing antimicrobial-resistant bacteria
|
some
|
Allison E. Aiello, Elaine L. Larson & Stuart B. Levy. 2007. Consumer antibacterial soaps: effective or just risky?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 2, S137-47.
|
|
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
|
some
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
The European Union Ecolabel program reports this substance is not anaerobically degradable.
|
some
|
EU Ecolabel: Detergents Ingredients Database
|
|
Toxic of swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
|
some
|
Cosmetic Ingredient Review (CIR): CIR Assessments
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
alters endocrine function in a variety of species
|
some
|
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
|
|
alters endocrine function in a variety of species
|
some
|
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
|
|
decreases thyroid hormone levels
|
some
|
Katie B. Paul, Joan M. Hedge, Ruby Bansal, R. Thomas Zoeller, Robert Peter, Michael J. Devito & Kevin M. Crofton. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: Dynamic and kinetic evaluation of a putative mode-of-action. Toxicology.
|
|
decreases thyroid hormone levels
|
some
|
Katie B. Paul, Joan M. Hedge, Michael J. Devito & Kevin M. Crofton. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicological sciences : an official journal of the Society of Toxicology 113(2), 367-79.
|
|
Triclosan may negatively affect immune function in people
|
some
|
Erin M. Rees Clayton, Megan Todd, Jennifer Beam Dowd & Allison E. Aiello. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental health perspectives 119(3), 390-6.
|
|
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
|
some
|
Tammy E. Stoker, Emily K. Gibson & Leah M. Zorrilla. 2010. Triclosan exposure modulates estrogen-dependent responses in the female wistar rat. Toxicological sciences : an official journal of the Society of Toxicology 117(1), 45-53.
|
|
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
|
some
|
Gennady Cherednichenko, Rui Zhang, Roger A. Bannister, Valeriy Timofeyev, Ning Li, Erika B. Fritsch, Wei Feng, Genaro C. Barrientos, Nils H. Schebb, Bruce D. Hammock, Kurt G. Beam, Nipavan Chiamvimonvat & Isaac N. Pessah. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35), 14158-63.
|
|
NTP Toxcast scored 2.5-3.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause respiratory irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye irritation
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
NTP Toxcast scored 1.5-2.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
|
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye damage
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
|
low
|
EU Ecolabel: Detergents Ingredients Database
|
|
The European Union Ecolabel program reports this substance in inherently biodegradable.
|
low
|
EU Ecolabel: Detergents Ingredients Database
|
|
The European Union Ecolabel program reports this substance is readily biodegradable.
|
low
|
EU Ecolabel: Detergents Ingredients Database
|
|
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
|
low
|
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
|
|
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
|
low
|
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
|
|
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
|
low
|
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
|
