|
Structurally related substances are classified by IARC as known, probable, and possible human carcinogens (International Agency for Research on Carcinogens).
|
moderate
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
May damage the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Causes damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Fatal if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Known To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
Suspected of causing genetic defects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Causes damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of causing cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause cancer
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Suspected of causing genetic defects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
May cause cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging fertility.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Probably carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
A review study found that cell-based screening tests suggest the potential for neurotoxicity.
|
some
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
Toxic if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic in contact with skin
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
confirmed human carcinogen
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
cancer
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
confirmed human carcinogen
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
cancer
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
lung cancer
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
peripheral nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
central nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
kidney damage
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
kidney damage
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
suspected human carcinogen
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
NTP Toxcast scored 2.5-3.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
|
NTP Toxcast scored 2.5-3.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
|
The European Commission's Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers reports this substance can irritate the skin.
|
some
|
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
|
|
Neurobehavioral effects observed in animal study.
|
some
|
Toyohito Tanaka, Osamu Takahashi, Akiko Inomata, Akio Ogata & Dai Nakae. 2012. Reproductive and neurobehavioral effects of brilliant blue FCF in mice. Birth defects research. Part B, Developmental and reproductive toxicology 95(6), 395-409.
|
|
may cause cancer
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
suspected of causing genetics defects
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
confirmed animal carcinogen with unknown relevance to humans
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Known To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
The Agency for Toxic Substances and Disease Registry reports this substance damages the cardiovascular system.
|
some
|
U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.
|
|
The Agency for Toxic Substances and Disease Registry reports this substance damages the immune system.
|
some
|
U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.
|
|
The Agency for Toxic Substances and Disease Registry reports this substance causes damage to the skin.
|
some
|
U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.
|
|
The Agency for Toxic Substances and Disease Registry reports this substance can damage the kidneys.
|
some
|
U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.
|
|
Known to cause reproductive toxicity (to females)
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Known to cause reproductive toxicity (to males)
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Known to cause reproductive toxicity
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
May damage the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging fertility.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Causes damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Fatal if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of causing genetic defects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
May cause cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging fertility.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of causing cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause cancer
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic in contact with skin
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
toxic if inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Toxic of swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Reasonably Anticipated To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Probably carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Toxic if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic in contact with skin
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
confirmed human carcinogen
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
cancer
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
lung cancer
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
Asthmagen (sensitizing)
|
some
|
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
|
|
central nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
peripheral nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
hematologic effects
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
kidney damage
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
EPA's review of industry submitted toxicity data and the potential for human exposure concludes that this substance poses a high risk for human health.
|
some
|
Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Risks
|
|
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
harmful in inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
suspected human carcinogen
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
The Agency for Toxic Substances and Disease Registry reports this substance shows some evidence of damage to the developing fetus.
|
some
|
U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.
|
|
Possibly carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
May cause damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Harmful if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
may cause cancer
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause harm to breast-fed children
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may damage fertility or the unborn child
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Fatal if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
fatal if inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
suspected of causing genetics defects
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause respiratory irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
confirmed animal carcinogen with unknown relevance to humans
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic in contact with skin
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
toxic if inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Toxic of swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye damage
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
upper respiratory tract irritation
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
may cause drowsiness or dizziness
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
harmful in inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
skin irritation
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause respiratory irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
May cause allergy or asthma symptoms of breathing difficulties if inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye damage
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
not classifiable as a human carcinogen
|
low
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
Not classifiable as to human carcinogenicity
|
low
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Not classifiable as to human carcinogenicity
|
low
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
not classifiable as a human carcinogen
|
low
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
EPA testing shows this substance has moderate acute toxicity to aquatic life
|
low
|
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
|
|
EPA testing shows this substance has low acute toxicity to aquatic life
|
low
|
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
|
|
EPA testing shows this substance has moderate acute toxicity to aquatic life
|
low
|
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
|
|
acute toxicity, oral LD50 (mg/kg)
|
low
|
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
|
|
EPA testing shows this substance has low acute toxicity to aquatic life
|
low
|
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
|
|
No evidence of reproductive or developmental toxicity in animal testing.
|
low
|
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
|
|
Little evidence of genotoxicity in animal or in vitro testing.
|
low
|
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
|
|
Not found to be carcinogenic in animal testing.
|
low
|
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
|
|
EFSA panel concluded there is no concern for genotoxicity.
|
low
|
European Food Safety Authority. 2010. Scientific Opinion on the re-evaluation of Brilliant Blue FCF (E 133) as a food additive. EFSA Journal 8(11), 1853.
|
