Health issue
Level of Concern
Source
A National Toxicology Program study found that dermal exposure to sodium xylene sulfonate could cause epidermal hyperplasia.
moderate
1998. NTP Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylenesulfonate (CAS No. 1300-72-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies). National Toxicology Program technical report series 464, 1-272.
The international Organisation for Economoic Co-operation and Development reported that the acute dermal LD50 for the hydrotrope calcium xylene sulfonate is greater than 624 mg/kg.
moderate
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The European Union Ecolabel program reports this substance is not anaerobically degradable.
some
EU Ecolabel: Detergents Ingredients Database
The international Organisation for Economoic Co-operation and Development reported that the lowest acute oral LD50 for the hydrotrope calcium xylene sulfonate is 1044 mg/kg.
some
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not skin irritants.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not skin sensitizers.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The European Union Ecolabel program reports this substance in inherently biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
This chemical has been verified to be of low concern in cleaning products based on experimental and modeled data as assessed by the EPA.
low
Environmental Protection Agency (EPA): Safer Chemical Ingredients List (2018-02-28)
European Union Ecolabel program data shows this substance has low chronic toxicity to aquatic life
low
EU Ecolabel: Detergents Ingredients Database
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
Only in: Household Cleaners
low
EU Ecolabel: Detergents Ingredients Database
The international Organisation for Economoic Co-operation and Development reported that the acute inhalation LC50 for the hydrotrope sodium toluene sulfonate is greater than 557 mg/L.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not genotoxic.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not carcinogenic via dermal exposure.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that the hydrotrope calcium xylene sulfonate is not teratogenic.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are not toxic to reproduction.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that hydrotropes are readily biodegradable under aerobic conditions.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
The international Organisation for Economoic Co-operation and Development reported that the lowest acute aquatic LC50 for hydrotropes is 230 mg/L.
low
Organisation for Economic Co-Operation and Development. 2005. Hydrotropes. SIDS Initial Assessment Profile for SIAM 21 October 18-20, 2005.
A National Toxicology Program study found no evidence that dermal exposure to sodium xylene sulfonate causes cancer.
low
1998. NTP Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylenesulfonate (CAS No. 1300-72-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies). National Toxicology Program technical report series 464, 1-272.