|
Synthetic food dyes are associated with adverse neurobehavioral outcomes in children.
Only in: Food Scores®
|
high
|
2021. Potential Neurobehavioral Effects of Synthetic Food Dyes in Children. California Environmental Protection Agency. Office of Environmental Health Hazard Assessment.
|
|
EFSA finds that there is "limited evidence" that Allura Red in a mixture with other synthetic colors and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population."
|
some
|
European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re-evaluation of Allura Red AC (E 129) as a food additive. EFSA Journal 7(11), 1327.
|
|
Suspected of causing genetic defects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of causing cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Causes damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause cancer
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
May cause cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Known to cause cancer
|
some
|
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
|
|
Causes damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Fatal if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
May damage the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of causing genetic defects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
May cause cancer
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Causes damage to organs through prolonged or repeated exposure
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Very toxic to aquatic life with long lasting effects
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Fatal if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging fertility.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Suspected of damaging the unborn child.
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Known To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Probably carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Reasonably Anticipated To Be Human Carcinogen
|
some
|
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
|
|
Probably carcinogenic to humans
|
some
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
Toxic if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic in contact with skin
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic if inhaled
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
peripheral nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
kidney damage
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
central nervous system impairment
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
EPA's review of industry submitted toxicity data and the potential for human exposure concludes that this substance poses a high risk for human health.
|
some
|
Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Risks
|
|
kidney damage
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
EFSA concludes that some sensitive individuals may experience allergic reactions at dose levels within the ADI.
|
some
|
European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re-evaluation of Allura Red AC (E 129) as a food additive. EFSA Journal 7(11), 1327.
|
|
suspected human carcinogen
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
Harmful if swallowed
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Possibly carcinogenic to humans
|
some
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
NTP Toxcast scored 2.5-3.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
|
A peer-reviewed study reports nervous system effects at the acceptable daily dose for humans.
|
some
|
Ali Noorafshan, Maedeh Hashemi, Saied Karbalay-Doust & Fatemeh Karimi. 2018. High dose Allura Red, rather than the ADI dose, induces structural and behavioral changes in the medial prefrontal cortex of rats and taurine can protect it. Acta histochemica 120(6), 586-594.
|
|
A peer-reviewed study reports that Red 40 affects the function of an enzyme important for the endocrine system.
|
some
|
Kanako Satoh, Rhouichi Nonaka, Fusako Ishikawa, Akio Ogata & Fumiko Nagai. 2008. In vitro screening assay for detecting aromatase activity using rat ovarian microsomes and estrone ELISA. Biological & pharmaceutical bulletin 31(3), 357-62.
|
|
Review article concluded that Red 40 caused hypersensitivity reactions.
|
some
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
Review article concluded that Red 40 caused hypersensitivity reactions.
|
some
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
suspected of causing genetics defects
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Fatal if swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
fatal if inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
confirmed animal carcinogen with unknown relevance to humans
|
some
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Toxic in contact with skin
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
toxic if inhaled
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Toxic of swallowed
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
|
some
|
EU GHS Hazard Labeling Codes: GHS Hazard Codes
|
|
Some data submitters indicate they consider this substance as Persistent, Bioaccumulative and Toxic
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
May cause an allergic skin reaction
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
may cause respiratory irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
NTP Toxcast scored 1.5-2.5
|
some
|
National Toxicology Program (NTP): EWG Toxcast Analysis
|
|
Causes skin irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
Causes serious eye damage
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
causes serious eye irritation
Only in: Household Cleaners
|
some
|
European Chemicals Agency (ECHA): GHS Data from ECHA Website
|
|
A review article reports equivocal evidence of carcinogenesis.
|
low
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
A review article reports equivocal evidence of carcinogenesis.
|
low
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
Not classified as a skin/eye irritant based on human, animal, and in vitro testing.
|
low
|
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Curry Red.
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Not classifiable as to its carcinogenicity to humans
|
low
|
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
|
|
Not classifiable as to human carcinogenicity
|
low
|
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
|
|
not classifiable as a human carcinogen
|
low
|
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
|
|
EPA testing shows this substance has moderate acute toxicity to aquatic life
|
low
|
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
|
|
Not classified as a skin/eye irritant based on human, animal, and in vitro testing.
|
low
|
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Curry Red.
|
|
Not a sensitizer based on limited human and animal tests.
|
low
|
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Curry Red.
|
|
A peer-reviewed article reports no evidence of genotoxicity in vivo.
|
low
|
Maria Bastaki, Thomas Farrell, Sachin Bhusari, Kamala Pant & Rohan Kulkarni. 2017. Lack of genotoxicity in vivo for food color additive Allura Red AC. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 105, 308-314.
|
|
A peer-reviewed study reports no genotoxicity in vivo.
|
low
|
Masamitsu Honma. 2015. Evaluation of the in vivo genotoxicity of Allura Red AC (Food Red No. 40). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 84, 270-5.
|
|
EPA testing shows this substance has low acute toxicity to aquatic life
|
low
|
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
|
|
A review article reports a lack of evidence of developmental toxicity.
|
low
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
A review article reports a lack of evidence of developmental toxicity.
|
low
|
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
|
|
acute toxicity, oral LD50 (mg/kg)
|
low
|
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Curry Red.
|
|
No evidence of developmental toxicity in animal testing.
|
low
|
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Curry Red.
|
|
No evidence of genotoxicity in vitro.
|
low
|
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Curry Red.
|
