Evidence
Health issue
Level of Concern
Source
Pegs
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
This substance is a PFAS, which is a chemical class of concern.
This substance is a PFAS, which is a chemical class of concern.
moderate
Carol F. Kwiatkowski, David Q. Andrews, Linda S. Birnbaum, Thomas A. Bruton, Jamie C. DeWitt, Detlef R. U. Knappe, Maricel V Maffini, Mark F. Miller, Katherine E. Pelch, Anna Reade, Anna Soehl, Xenia Trier, Marta Venier, Charlotte C. Wagner, Zhanyun Wang & Arlene Blum. 2020. Scientific Basis for Managing PFAS as a Chemical Class. Environmental science & technology letters 7(8), 532-543.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
some
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Pegs
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
some
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Impurities
Health issue
Level of Concern
Source
Pegs
Impurity: ETHYLENE OXIDE
May cause genetic defects
Impurity: ETHYLENE OXIDE
May cause genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: ETHYLENE OXIDE
May cause cancer
Impurity: ETHYLENE OXIDE
May cause cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: ETHYLENE OXIDE
Known to cause cancer
Impurity: ETHYLENE OXIDE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Pegs
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to females)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to females)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Pegs
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to males)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to males)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Pegs
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Pegs
Impurity: ETHYLENE OXIDE
Carcinogenic to humans
Impurity: ETHYLENE OXIDE
Carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Pegs
Impurity: ETHYLENE OXIDE
Known To Be Human Carcinogen
Impurity: ETHYLENE OXIDE
Known To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Pegs
Impurity: 1,4-DIOXANE
Suspected of causing cancer
Impurity: 1,4-DIOXANE
Suspected of causing cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: 1,4-DIOXANE
Known to cause cancer
Impurity: 1,4-DIOXANE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Pegs
Impurity: 1,4-DIOXANE
Reasonably Anticipated To Be Human Carcinogen
Impurity: 1,4-DIOXANE
Reasonably Anticipated To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Pegs
Impurity: ETHYLENE OXIDE
Toxic if inhaled
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: ETHYLENE OXIDE
Causes pulmonary edema
Impurity: ETHYLENE OXIDE
Causes pulmonary edema
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
Impurity: ETHYLENE OXIDE
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
Causes reproductive effects
Impurity: ETHYLENE OXIDE
Causes reproductive effects
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
Causes leukemia
Impurity: ETHYLENE OXIDE
Causes leukemia
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
Causes peritoneal cancer
Impurity: ETHYLENE OXIDE
Causes peritoneal cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
cancer
Impurity: ETHYLENE OXIDE
cancer
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Pegs
Impurity: ETHYLENE OXIDE
central nervous system impairment
Impurity: ETHYLENE OXIDE
central nervous system impairment
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Pegs
Impurity: ETHYLENE OXIDE
Asthmagen (irritation)
Impurity: ETHYLENE OXIDE
Asthmagen (irritation)
some
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Pegs
Impurity: 1,4-DIOXANE
Causes cancer
Impurity: 1,4-DIOXANE
Causes cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: 1,4-DIOXANE
liver damage
Impurity: 1,4-DIOXANE
liver damage
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Pegs
Impurity: ETHYLENE OXIDE
suspected human carcinogen
Impurity: ETHYLENE OXIDE
suspected human carcinogen
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Pegs
Impurity: 1,4-DIOXANE
Possibly carcinogenic to humans
Impurity: 1,4-DIOXANE
Possibly carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Pegs
Impurity: 1,4-DIOXANE
confirmed animal carcinogen with unknown relevance to humans
Impurity: 1,4-DIOXANE
confirmed animal carcinogen with unknown relevance to humans
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Pegs
Impurity: ETHYLENE OXIDE
May cause respiratory irritation
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: 1,4-DIOXANE
May cause respiratory irritation
Only in: Household Cleaners
Impurity: 1,4-DIOXANE
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: ETHYLENE OXIDE
Causes respiratory irritation
Impurity: ETHYLENE OXIDE
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: 1,4-DIOXANE
Causes respiratory irritation
Impurity: 1,4-DIOXANE
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
Harmful if swallowed
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Pegs
Impurity: ETHYLENE OXIDE
Causes skin irritation
Impurity: ETHYLENE OXIDE
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
Impurity: ETHYLENE OXIDE
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: 1,4-DIOXANE
Causes skin irritation
Impurity: 1,4-DIOXANE
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Pegs
Impurity: ETHYLENE OXIDE
may cause respiratory irritation
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Pegs
Impurity: ETHYLENE OXIDE
Causes serious eye irritation
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: 1,4-DIOXANE
Causes serious eye irritation
Only in: Household Cleaners
Impurity: 1,4-DIOXANE
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Pegs
Impurity: ETHYLENE OXIDE
Causes serious eye damage
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Pegs
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Pegs
Impurity: ETHYLENE OXIDE
causes serious eye irritation
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Pegs
Impurity: ETHYLENE OXIDE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Impurity: ETHYLENE OXIDE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Pegs
Impurity: 1,4-DIOXANE
EPA testing shows this substance has low acute toxicity to aquatic life
Impurity: 1,4-DIOXANE
EPA testing shows this substance has low acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database