EPA's review of industry submitted toxicity data concludes that this substance poses a high hazard based on the possibility of persistence, bioaccumulation, aquatic toxicity and impacts to human health.
|
moderate
|
Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Hazards
|
No skin sensitization was observed in human or animal tests.
|
low
|
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.
|
Low toxicity observed in various aquatic organisms.
|
low
|
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.
|
No genotoxicity observed in a bacterial cell assay. A related substance was not genotoxic in an in vivo assay with mice.
|
low
|
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.
|
A related substance was not shown to be toxic to reproduction or development in animal tests.
|
low
|
A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.
|
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
|
low
|
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
|